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Efficacy of amitriptyline in headache prophylaxis | Synapse
March 3, 2026
Efficacy of amitriptyline in headache prophylaxis
BL
Bruna Leite
University of Minho
DN
Daniel P. Ayres Neto
Fundação Faculdade de Medicina
WH
Wagner Gonçalves Horta
Universidade Católica de Pernambuco
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Puntos clave
Headache prophylaxis significantly improves when amitriptyline is administered, reducing episodes over time.
Amitriptyline shows a notable 40% reduction in headache frequency among individuals with migraines.
Observational analysis across various clinics highlights the positive impact of amitriptyline on chronic headache management.
This suggests that interventions may enhance patient quality of life, though individual responses can vary.
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Leite et al. (Mon,) studied this question.
synapsesocial.com/papers/69a75f0bc6e9836116a2a243
https://doi.org/https://doi.org/10.1016/j.jns.2025.124699
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