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Sitagliptin alleviates cyclophosphamide-induced oxidative stress and testicular toxicity in Wistar rats | Synapse
March 3, 2026
Sitagliptin alleviates cyclophosphamide-induced oxidative stress and testicular toxicity in Wistar rats
SM
Shabnam Moradi
NK
Nasrin Kazemipour
MD
Mohammad Reza Divar
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Puntos clave
Sitagliptin reduces testicular toxicity caused by cyclophosphamide, improving overall testicular health.
The treatment significantly lowers markers of oxidative stress, providing protective effects on the testes.
Analysis in Wistar rats demonstrates that antioxidants may play a key role in mitigating drug side effects.
Findings suggest that sitagliptin could lead to safer treatment options for conditions requiring cyclophosphamide.
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Moradi et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75f27c6e9836116a2a50a
https://doi.org/https://doi.org/10.1007/s00580-026-03743-9