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Dropped head syndrome following dose escalation of donepezil | Synapse
March 3, 2026
Dropped head syndrome following dose escalation of donepezil
SP
Sang Jin Park
DS
Dong-Ick Shin
Puntos clave
Dropped head syndrome developed after increasing the donepezil dosage, affecting neck muscle tone.
Patient demonstrated significant decline in cognitive function alongside physical symptoms within weeks post-escalation.
Observational analysis of dosage effects, detailing the timeline of neurological changes and physical presentations.
This case highlights the need for monitoring neuromuscular symptoms following treatments like donepezil; further investigation is warranted.
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Cite This Study
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Park et al. (Mon,) studied this question.
synapsesocial.com/papers/69a75f43c6e9836116a2a817
https://doi.org/https://doi.org/10.1016/j.jns.2025.124757