TGF-β in tumor development and progression: mechanisms and therapeutics

Puntos clave

• Tumor progression is driven by TGF-β signaling pathways, influencing cellular behavior and microenvironment.
• Key evidence shows that high TGF-β levels correlate with increased tumor growth in various cancers.
• Analysis of biological mechanisms reveals TGF-β's complex role in immune evasion and metastasis.
• Understanding TGF-β could lead to targeted therapies, enhancing cancer treatment options and patient outcomes.