Dose Heterogeneity in Transarterial Radioembolization after Fractional Administration of Holmium Microspheres: A Study in Perfused Human Tumor-Bearing Liver Explants under MR Imaging

Puntos clave

• Dose heterogeneity impacts both liver tumors and surrounding nontumor regions, complicating treatment assessments.
• Fine-scale distributions reveal variability below standard imaging resolution, indicating potential clinical concerns.
• This observational analysis uses human tumor-bearing liver explants subjected to MR imaging to assess microsphere behavior.
• Further investigation is needed to fully understand the clinical relevance of these findings on treatment efficacy.