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PBX1-mediated transcription of AP1M2 promotes triple-negative breast cancer malignant progression and docetaxel resistance | Synapse
March 3, 2026
PBX1-mediated transcription of AP1M2 promotes triple-negative breast cancer malignant progression and docetaxel resistance
RC
Ruijie Cui
Xinxiang Central Hospital
HC
Hongli Chen
Shanghai University
XZ
Xin Zhao
Xinxiang Central Hospital
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Puntos clave
Docetaxel resistance affects treatment outcomes in patients with triple-negative breast cancer, complicating management of the disease.
The study finds higher levels of PBX1 and AP1M2 are associated with increased malignant behavior and worse prognosis in breast cancer.
Transcriptional regulation by PBX1 was analyzed using cancer cell lines and clinical samples to understand its role in cancer progression.
Further investigations may target PBX1 to overcome docetaxel resistance in future therapeutic strategies.
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Cite This Study
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Cui et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75f81c6e9836116a2aeb9
https://doi.org/https://doi.org/10.1016/j.gene.2026.150031