PPARγ activation rescues oxidative stress-induced embryonic arrest by suppressing Wnt/β-catenin signaling via GSK3β upregulation

Puntos clave

• Embryonic arrest was rescued by PPARγ activation, demonstrating a potential link to oxidative stress suppression.
• Activation of PPARγ significantly inhibited Wnt/β-catenin signaling, which is known to be affected by oxidative stress levels.
• GSK3β was upregulated as part of the mechanism, revealing a pivotal role in the signaling cascade.
• Findings may enable novel therapeutic approaches for managing embryonic development and related disorders.