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Impact of Losing Unit–Recipient HLA Mismatch on Relapse and Outcomes after Double Cord Blood Transplantation | Synapse
March 3, 2026
Impact of Losing Unit–Recipient HLA Mismatch on Relapse and Outcomes after Double Cord Blood Transplantation
LR
Laura Roberts
AD
Ann Dahlberg
Seattle Children's Hospital
AA
Alessandra Azure
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Puntos clave
Reduced relapse rates were observed with fewer HLA mismatches in double cord blood transplantation recipients, highlighting improved transplant outcomes.
Patients experiencing lower HLA mismatch had a 30% decrease in relapse occurrences, indicating strong metrics for treatment efficacy.
Analysis involved reviewing clinical data from recipients of double cord blood transplants, focusing on HLA mismatch impacts.
This finding supports further exploration of HLA compatibility's role in enhancing outcomes, especially in hematopoietic stem cell transplantation.
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Roberts et al. (Sun,) studied this question.
synapsesocial.com/papers/69a7601ac6e9836116a2c85e
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.307