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Multiple Vertebral Fractures After One Dose of Denosumab | Synapse
March 3, 2026
Open Access
Multiple Vertebral Fractures After One Dose of Denosumab
JR
Jaime Leigh Ryan
LE
Leslie S. Eldeiry
Puntos clave
Multiple vertebral fractures occurred in patients after a single dose of denosumab, highlighting a significant concern.
The rate of fractures increased among individuals with previously low bone density levels, emphasizing vulnerability.
Analysis focused on patient histories and bone density metrics, showing the need for careful assessment prior to treatment.
This finding calls for further investigation into the long-term effects of denosumab on fracture risk, especially in vulnerable populations.
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Ryan et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76028c6e9836116a2ca1b
https://doi.org/https://doi.org/10.1016/j.aed.2026.01.014
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