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Comparison of Leukapheresis Products from Patients with AML and ALL Suggests Increased T-cell Exhaustion Among Patients with AML | Synapse
March 3, 2026
Comparison of Leukapheresis Products from Patients with AML and ALL Suggests Increased T-cell Exhaustion Among Patients with AML
AD
Alexandra Dreyzin
National Institutes of Health
JR
Joseph M Rocco
AC
Anna Cantilena
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Puntos clave
T-cell exhaustion appears more pronounced in leukapheresis products of AML patients, indicating a potential biomarker.
Comparative analysis shows an increase in inhibitory receptors on T-cells in AML compared to ALL.
Assessment examined leukapheresis products from patients diagnosed with AML and ALL to uncover differences.
Findings highlight the need to address T-cell exhaustion in AML treatment strategies for better outcomes.
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Cite This Study
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Dreyzin et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76037c6e9836116a2cbb7
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.883