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Superior Long-Term Survival with Fludarabine-Melphalan RIC Regimen in Older AML/MDS Patients: A Propensity Score Analysis of CIBMTR Data | Synapse
March 3, 2026
Superior Long-Term Survival with Fludarabine-Melphalan RIC Regimen in Older AML/MDS Patients: A Propensity Score Analysis of CIBMTR Data
PK
Piyanuch Kongtim
University of California, Irvine
AP
Andrew J. Portuguese
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
KS
Kim Soyoung
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Puntos clave
Survival rates significantly increase with the fludarabine-melphalan regimen over traditional treatments.
Key evidence reveals a 25% improvement in long-term survival for older AML/MDS patients using this regimen.
Propensity score analysis utilized data from the CIBMTR, ensuring robust comparisons across patient demographics.
The findings support the need for tailored therapies in older populations facing leukemia and myelodysplastic syndromes.
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Kongtim et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76040c6e9836116a2cd04
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.083
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