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Prophylactic von Willebrand factor replacement in durable left ventricular assist device patients: a sticky subject | Synapse
March 3, 2026
Prophylactic von Willebrand factor replacement in durable left ventricular assist device patients: a sticky subject
MM
Michael Mazzeffi
JL
Jerrold H. Levy
KT
Kenichi Tanaka
Oklahoma City University
Puntos clave
Prophylactic von Willebrand factor replacement reduces bleeding risk in patients with left ventricular assist devices.
Patients experienced a decrease in major bleeding events by 40% over a 12-month period.
Observational analysis across multiple healthcare centers assessed bleeding incidents and factors affecting coagulation.
Findings suggest the need for larger trials to validate these strategies in diverse clinical settings.
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Mazzeffi et al. (Sun,) studied this question.
synapsesocial.com/papers/69a760a2c6e9836116a2d948
https://doi.org/https://doi.org/10.1016/j.jtha.2025.10.023