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From brain to eye: Annexin A1 and A2 as a key mediator of retinal neuroinflammation in Parkinson’s and Alzheimer’s disease | Synapse
March 3, 2026
Open Access
From brain to eye: Annexin A1 and A2 as a key mediator of retinal neuroinflammation in Parkinson’s and Alzheimer’s disease
LF
Luiz Philipe de Souza Ferreira
Universidade Federal de São Paulo
CR
Caio Vinicius Saito Regatieri
Universidade Federal de São Paulo
Puntos clave
Annexin A1 and A2 are implicated in neuroinflammation of the retina, highlighting their significance in neurodegenerative diseases.
Analysis reported increased levels of annexin proteins in retinal tissue from patients with Alzheimer’s and Parkinson’s disease.
Observational analysis suggests these annexins could serve as biomarkers for disease progression in neurodegenerative disorders.
Further investigation into annexin pathways may provide new approaches for treatment in Alzheimer's and Parkinson's diseases.
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Ferreira et al. (Wed,) studied this question.
synapsesocial.com/papers/69a760a7c6e9836116a2d9c8
https://doi.org/https://doi.org/10.1186/s40942-025-00786-y
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