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Precision targeting of the SASP in cancer therapy | Synapse
March 3, 2026
Precision targeting of the SASP in cancer therapy
SH
Saima Hassan
Centre Hospitalier de l’Université de Montréal
GF
Gerardo Ferbeyre
HEC Montréal
Puntos clave
Modulating the senescence-associated secretory phenotype (SASP) enhances cancer therapy outcomes, indicating a promising path for treatment.
Significant reduction in inflammatory cytokines was observed during targeted interventions, highlighting a key effect of modulation.
Preclinical analyses involving various cancer models support the effectiveness of SASP targeting in tumor treatment approaches.
Targeting the SASP may drive future precision therapies, emphasizing the need for further validation in broader contexts.
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Hassan et al. (Tue,) studied this question.
synapsesocial.com/papers/69a760b2c6e9836116a2dae9
https://doi.org/https://doi.org/10.1038/s43587-025-01052-4
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