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Ciltacabtagene Autoleucel out-of-Specification Manufacturing Outcomes Improve with Earlier Lines of Therapy | Synapse
March 3, 2026
Ciltacabtagene Autoleucel out-of-Specification Manufacturing Outcomes Improve with Earlier Lines of Therapy
RB
Robert Bowden
GC
Gourav Choudhary
LK
Lisa R. Kallenbach
Johnson & Johnson (United States)
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Puntos clave
Improved manufacturing outcomes are associated with earlier lines of therapy for ciltacabtagene autoleucel.
Key metrics demonstrate a significant reduction in out-of-specification rates when earlier therapies are administered.
Analysis of manufacturing processes indicates that adjustments can lead to better performance metrics across therapy lines.
May enable more effective use of ciltacabtagene autoleucel in treatment regimens, potentially enhancing patient outcomes.
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Bowden et al. (Sun,) studied this question.
synapsesocial.com/papers/69a760b6c6e9836116a2db4e
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.233