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Immune Reconstitution Associated with CMV Reactivation after Discontinuation of Letermovir Prophylaxis - a Prospective Study | Synapse
March 3, 2026
Immune Reconstitution Associated with CMV Reactivation after Discontinuation of Letermovir Prophylaxis - a Prospective Study
AP
Agnieszka Piekarska
PS
Patryk Sobieralski
Nicolaus Copernicus University
AL
Anna Lojko–Dankowska
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Puntos clave
CMV reactivation occurs after discontinuing letermovir prophylaxis, indicating immune reconstitution is significant.
In the study, 30% of patients experienced CMV reactivation within three months post-prophylaxis discontinuation.
Observational analysis among patients treated with letermovir for CMV showed a connection to immune system recovery.
Findings highlight the need for monitoring CMV during immune reconstitution after prophylaxis stops.
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Cite This Study
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Piekarska et al. (Sun,) studied this question.
synapsesocial.com/papers/69a760bcc6e9836116a2dc46
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.798