Revisiting fractionation in prostate carbon ion therapy: first comparative analysis of biologically effective dose using mMKM with diverse parameters

Puntos clave

• Biologically effective dose increases with optimized fractionation strategies and diverse parameters, leading to better treatment outcomes.
• The analysis shows a notable improvement in dose delivery metrics compared to conventional methods, enhancing therapeutic efficacy.
• Observational analysis using mixed multivariate kinetic models (mMKM) across various fractional doses and configurations allows nuanced insights.
• These findings highlight the importance of tailored treatment parameters, forwarding advancements in carbon ion therapy applications.