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A comprehensive analysis of epigenetic mechanisms regulating inflammation-induced TNF-α gene expression by small-molecule inhibitor screening | Synapse
March 3, 2026
A comprehensive analysis of epigenetic mechanisms regulating inflammation-induced TNF-α gene expression by small-molecule inhibitor screening
KW
Komal Paresh Walvekar
SA
Sai Balaji Andugulapati
Laboratory of Molecular Genetics
SC
Sabarinadh Chilaka
Puntos clave
Gene expression regulation shows significant influence from epigenetic mechanisms in inflammation context.
The study utilizes small-molecule inhibitor screening to identify key regulatory pathways affecting TNF-α levels.
Comprehensive analysis focused on epigenetic mechanisms reveals critical insights into inflammation modulation.
Results may enable novel approaches for therapies targeting inflammation-related conditions.
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Walvekar et al. (Tue,) studied this question.
synapsesocial.com/papers/69a760cec6e9836116a2de7d
https://doi.org/https://doi.org/10.1007/s11033-026-11514-6