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Successful bioequivalence prediction of immediate-release vortioxetine tablets through prospective virtual crossover and parallel trials | Synapse
March 3, 2026
Successful bioequivalence prediction of immediate-release vortioxetine tablets through prospective virtual crossover and parallel trials
DD
Dorota Danielak
Department of Physiological Sciences
MS
Marcela Staniszewska
University of Wrocław
SR
Svitlana Romanova
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Puntos clave
Successful bioequivalence prediction indicates effectiveness of virtual trials in drug assessment.
Using virtual crossover and parallel trials, bioequivalence metrics showed high reliability with vortioxetine tablets.
Assessment using innovative trial designs allows for faster predictions in pharmaceutical development.
This work may enable streamlined processes in drug approval, reducing time and costs of clinical studies.
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Danielak et al. (Sat,) studied this question.
synapsesocial.com/papers/69a76147c6e9836116a2f108
https://doi.org/https://doi.org/10.1016/j.xphs.2026.104208