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PINK1 deacetylation by emodin-induced SIRT3 upregulation alleviates acute kidney injury by Inhibition of ferroptosis | Synapse
March 3, 2026
PINK1 deacetylation by emodin-induced SIRT3 upregulation alleviates acute kidney injury by Inhibition of ferroptosis
RW
Rui Wang
ZZ
Ziwei Zou
Hubei University of Chinese Medicine
YA
Yi An
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Puntos clave
Acute kidney injury is alleviated, highlighting the role of SIRT3 in mitigating ferroptosis.
SIRT3 upregulation through emodin positively impacts PINK1 deacetylation.
Inhibition of ferroptosis provides a protective effect on kidney cells during injury periods.
Further exploration of this pathway could lead to new therapies for treating acute kidney injury.
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Cite This Study
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Wang et al. (Tue,) studied this question.
synapsesocial.com/papers/69a761adc6e9836116a2fb87
https://doi.org/https://doi.org/10.1007/s00011-025-02137-x