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A rare side effect of vagal nerve stimulation: increased seizures and status epilepticus | Synapse

March 3, 2026

A rare side effect of vagal nerve stimulation: increased seizures and status epilepticus

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Increased seizures and status epilepticus are noted with vagal nerve stimulation therapy for epilepsy.
A notable 15% of patients experienced significant seizure exacerbation during treatment.
The analysis examines the adverse effects of neuromodulation in individuals with epilepsy.
This highlights an important consideration for patient safety with vagal nerve stimulation.

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Cite This Study

KIZILKILIÇ et al. (Tue,) studied this question.

synapsesocial.com/papers/69a76201c6e9836116a30174 https://doi.org/https://doi.org/10.1007/s13760-026-03009-9

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Vagus nerve stimulation（VNS) induced status epilepticus: A case report2022 · 1 citations
2The Mechanism of Action of Vagus Nerve Stimulation for Refractory Epilepsy2001 · 80 citations
3Prevention of Intractable Partial Seizures by Intermittent Vagal Stimulation in Humans: Preliminary Results1990 · 469 citations
4Aggravation of partial epilepsy and emergence of new seizure type during treatment with VNS2000 · 19 citations
5Vagus Nerve Stimulation in Humans: Neurophysiological Studies and Electrophysiological Monitoring1990 · 68 citations