Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

Puntos clave

• Glucagon secretion is inhibited by glucagon-like peptide-1, not by glucose-dependent insulinotropic peptide.
• Key evidence shows that somatostatin receptor subtype 2 mediates this inhibition in the rat's pancreas.
• Analysis utilized a perfused rat pancreas model to investigate the hormonal interactions.
• Findings highlight the distinct roles of glucagon-like peptide-1 and glucose-dependent insulinotropic peptide in endocrine regulation.