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Retraction for Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation | Synapse
March 3, 2026
Open Access
Retraction for Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation
YH
Yujiao Han
HF
Heng Feng
JS
Jun Sun
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Puntos clave
Osteogenic tumors develop due to Lkb1 deletion, activating mTORC1 signaling.
Findings revealed a significant 50% incidence of tumors in the studied models.
Analysis involved the deletion of Lkb1 in periosteal mesenchymal progenitor cells.
Retraction highlights the need for caution in interpreting Lkb1's role in tumorigenesis.
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Han et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76564badf0bb9e87d8f25
https://doi.org/https://doi.org/10.1172/jci204387
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