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CaMKII-based gene therapy protects retinal ganglion cells in a broad range of disease: ischemic retinopathy and congenital glaucoma | Synapse
March 3, 2026
CaMKII-based gene therapy protects retinal ganglion cells in a broad range of disease: ischemic retinopathy and congenital glaucoma
JZ
Jing Zhou
Zhejiang Sci-Tech University
YW
Yue Wan
MA
Michael G. Anderson
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Puntos clave
Retinal ganglion cells are better protected, demonstrating significant therapeutic effects from CamKII-based gene therapy.
The gene therapy intervention improved neuronal survival, with effects observed across multiple disease conditions.
This analysis involved cellular models reflecting ischemic retinopathy and congenital glaucoma, evaluating cell health over time.
Findings suggest that CamKII-targeted therapies could enhance treatment strategies for various retinal diseases.
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Cite This Study
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Zhou et al. (Sun,) studied this question.
synapsesocial.com/papers/69a765b6badf0bb9e87da22d
https://doi.org/https://doi.org/10.1016/j.ymthe.2026.01.036