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Customizing CRISPR–Cas PAM specificity with protein language models | Synapse
March 3, 2026
Customizing CRISPR–Cas PAM specificity with protein language models
SN
Stephen Nayfach
Bio-Medical Science (South Korea)
AB
Aadyot Bhatnagar
Joint BioEnergy Institute
AN
Andrey Novichkov
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Puntos clave
Enhanced PAM specificity achieved through protein language models, allowing for more precise gene editing applications.
The customization process utilizes novel techniques in genetic engineering, broadening potential for diverse applications.
Approach involves innovative use of protein language models to improve CRISPR-Cas technology for gene editing.
Highlights the importance of PAM specificity in CRISPR systems, emphasizing the need for further studies on protein interactions.
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Nayfach et al. (Mon,) studied this question.
synapsesocial.com/papers/69a765b9badf0bb9e87da302
https://doi.org/https://doi.org/10.1038/s41587-025-02995-0
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