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From flavones to flavanols: An enzymatic kinetic resolution approach to enantioenriched 2-(het)arylchroman-4-ols | Synapse
March 3, 2026
From flavones to flavanols: An enzymatic kinetic resolution approach to enantioenriched 2-(het)arylchroman-4-ols
OT
Oleksii S. Timokhin
VH
Vladyslav V. Hys
OK
Olexandr V. Kucher
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Puntos clave
Enzymatic resolution produces enantioenriched chroman-4-ols, enhancing compound diversity and application.
Results demonstrate a notable enantioselectivity of 92% for the target flavanol compound in this approach.
Analysis using kinetic resolution techniques allows for efficient synthesis of varied flavanols from flavones.
Implications suggest potential for creating new flavanoid derivatives and improving pharmaceutical applications.
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Timokhin et al. (Tue,) studied this question.
synapsesocial.com/papers/69a7667bbadf0bb9e87dd295
https://doi.org/https://doi.org/10.1016/j.tet.2026.135174