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Differentiation of mesenchymal stem/stromal cells into CD45+ macrophage-like cells: expanding insights into MSC plasticity | Synapse
March 3, 2026
Open Access
Differentiation of mesenchymal stem/stromal cells into CD45+ macrophage-like cells: expanding insights into MSC plasticity
RR
Robert Rusch
Fujita Health University
YM
Yo Mabuchi
SM
Satoru Morikawa
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Puntos clave
Macrophage-like cells can arise from mesenchymal stem cells, highlighting their plasticity.
Key findings include increased CD45 expression during differentiation, indicating immune characteristics.
This work employs a differentiation approach to analyze mesenchymal stem cell plasticity and immune response.
Findings suggest further exploration in therapeutics and immune modulation using plasticity of stem cells.
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Rusch et al. (Fri,) studied this question.
synapsesocial.com/papers/69a766d9badf0bb9e87deaa5
https://doi.org/https://doi.org/10.1016/j.isci.2026.114906