PFKFB3 nuclear translocation improves diabetic retinopathy by attenuating endothelial cell senescence through inhibition of USP7-p53 axis

Puntos clave

• Nuclear translocation of PFKFB3 improves diabetic retinopathy by reducing endothelial cell senescence.
• Evidence shows a significant inhibition of the USP7-p53 axis, suggesting a key mechanism at play.
• Analysis focused on cellular behavior in diabetic conditions, emphasizing the role of senescence.
• Highlighting the potential for targeted interventions in endothelial senescence could improve therapeutic strategies.