Integrative dual ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumor transcription and resistance phenotypes in metastatic prostate cancer | Synapse
March 3, 2026Open Access
Integrative dual ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumor transcription and resistance phenotypes in metastatic prostate cancer
Puntos clave
Tumor transcription and resistance phenotypes are inferred from dual ctDNA analysis, indicating distinct cancer traits.
Key evidence shows that 5mC/5hmC methylation patterns provide crucial insights into tumor behavior in prostate cancer.
Integrative analysis of ctDNA methylomics and clonal reconstruction was utilized to assess cancer characteristics and dynamics.
Highlighting clonal evolution in metastatic disease may guide future therapeutic strategies and personalized treatment approaches.