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Structural basis for pan-coronavirus inhibition of 3CL protease | Synapse
March 3, 2026
Structural basis for pan-coronavirus inhibition of 3CL protease
ER
Eswar R. Reddem
Columbia University
FF
F. Forouhar
Columbia University Irving Medical Center
CL
Cheng Liu
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Puntos clave
Inhibition of 3CL protease is crucial for blocking coronavirus replication, potentially curbing infections.
Key evidence shows structural data indicating effective inhibition of 3CL protease across multiple coronavirus strains.
Analysis of structural biology techniques elucidates the interactions between inhibitors and viral enzymes efficiently.
Highlighting the findings supports the need for developing broad-spectrum antiviral therapies targeting 3CL protease.
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Reddem et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76799badf0bb9e87e1962
https://doi.org/https://doi.org/10.1016/j.str.2026.01.003
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