An ex vivo gut mucosal explant assay to compare HIV tissue susceptibility shows increased HIV susceptibility with methamphetamine exposure

Puntos clave

• Increased HIV susceptibility is observed in mucosal tissue exposed to methamphetamine, highlighting potential risks.
• The assay detects subtle changes in viral production and transfer, measuring mucosal susceptibility effectively.
• Utilizing an ex vivo explant assay, this work demonstrates the impact of substance use on HIV transmission risk.
• Findings suggest further investigation into prevention strategies and the role of host and microbial factors in HIV susceptibility.