Proinflammatory cytokines modify Ca2+ signaling and induce an apoptotic lipidome in murine small intestinal organoids
Puntos clave
Calcium signaling is transiently upregulated by proinflammatory cytokines, affecting cell behavior.
Apoptotic changes in the lipidome are induced alongside modifications in calcium signaling.
Murine small intestinal organoids were utilized to study the effects of cytokines on cellular processes.
Understanding these mechanisms highlights potential targets for therapeutic intervention in gut diseases.
Resumen
Proinflammatory cytokines induce fluid secretion and transiently upregulate Ca2+ signaling concomitant with the induction of an apoptotic lipidome in small intestinal organoids.