12,13-diHOME ameliorates MASLD by regulating Sestrin2-mediated AMPK/ULK1/Lipophagy in obese mice

Puntos clave

• 12,13-diHOME significantly ameliorates MASLD, showing promise as a therapeutic agent.
• The study identifies Sestrin2 as a key regulator in the AMPK/ULK1/lipophagy pathway for treatment.
• Analysis of metabolic processes in obese mice reveals critical interactions affecting disease.
• These findings suggest potential new strategies for addressing liver diseases associated with obesity.