Farnesol induces apoptosis, LC3B/SQSTM1 mediated regulation of autophagy and downregulates anaerobic Glycolysis through suppression of LDH and PKM in A549 lung adenocarcinoma cells | Synapse
March 3, 2026
Farnesol induces apoptosis, LC3B/SQSTM1 mediated regulation of autophagy and downregulates anaerobic Glycolysis through suppression of LDH and PKM in A549 lung adenocarcinoma cells
Puntos clave
Farnesol induces apoptosis in A549 lung adenocarcinoma cells, leading to cell death.
Key metrics include downregulation of LDH and PKM, which are critical in glycolysis.
Assessment of autophagy highlights the role of LC3B and SQSTM1 in cellular processes.
Results indicate that targeting these pathways may enhance cancer treatment efficacy.
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Muthuvenugopal et al. (Thu,) studied this question.