In this study, the structural characterization and hypolipidemic activity in vivo of finger citron polysaccharide (FCP) were investigated. The FCP consisted of →t)-Ara(f)-(1→, →5)-Ara(f)-(1→, and →4)-Gal(p)-UA-(1→ with the molecular weight of 46.35 KDa. FCP significantly decreased the levels of total cholesterol (TC), triglyceride (TG), low density cholesterol (LDL-C), phenylpropionate aminotransferase (ALT), and aspartate aminotransferase (AST) and increased the level of high density cholesterol (HDL C) in the serum of mice ( P < 0.05). Besides, FCP could significantly improve the antioxidant enzymes activities and decreased the liver lipid metabolism indexes ( P < 0.05). AMPK/ACC and PPARα/LXRα were used to investigate the hypolipidemic mechanism of FCP, which indicated that FCP could up-regulate the protein and gene levels of AMPK, acetyl-CoA carboxylase(ACC), PPARα and LXRα. This study provides an important basis of FCP for inhibiting the occurrence of metabolic disorders such as hyperlipemia and complications. • Finger Citron polysaccharide (FCP-N2) emerges as a potent hypolipidemic functional food with well-defined structural features. • FCP-N2 effectively normalizes serum lipid profiles and alleviates liver injury in high-fat diet-induced hyperlipidemic mice. • It enhances hepatic antioxidant capacity and regulates key enzymes involved in lipid synthesis and catabolism. • FCP-N2 exerts hypolipidemic effects through synergistic regulation of AMPK/ACC and PPARα/LXRα signaling pathways.
Ma et al. (Thu,) studied this question.