What does this research mean for the field?

Polycystic ovary syndrome (PCOS) significantly impairs health-related quality of life, particularly psychological well-being, with higher BMI and urban residence identified as key determinants. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This research aims to evaluate health-related quality of life in women with polycystic ovary syndrome (PCOS) and identify factors that influence it.

March 5, 2026Open Access

Impact of Polycystic Ovary Syndrome on Health-Related Quality of Life: A Cross-Sectional Study Using the PCOSQOL Scale

Puntos clave

This research aims to evaluate health-related quality of life in women with polycystic ovary syndrome (PCOS) and identify factors that influence it.
Conducted a hospital-based cross-sectional study among 125 women aged 15-35 years with PCOS.
Assessed quality of life using the 35-item PCOSQOL scale.
Collected sociodemographic and clinical variables for analysis.
Applied Pearson correlation, independent t-tests, and multivariable linear regression for data analysis.
Mean age of participants was 21.26 years with a BMI of 23.56 kg/m².
Mood had the lowest quality of life score among the domains measured.
Higher BMI correlated negatively with quality of life scores across all domains.
In adjusted models, higher BMI independently predicted poorer quality of life scores in various aspects including mood and infertility.
Urban residence was associated with poorer mood quality of life outcomes.

Resumen

Background: Polycystic ovary syndrome (PCOS) is associated with metabolic and psychological morbidity, yet limited Indian data using disease-specific quality-of-life instruments exist. This study assessed health-related quality of life (QoL) using the PCOSQOL scale and identified sociodemographic and clinical predictors. Methods: A hospital-based cross-sectional study was conducted among 125 women aged 15-35 years with PCOS diagnosed by Rotterdam criteria at a tertiary care hospital in Hyderabad. QoL was measured using the 35-item PCOSQOL instrument. Sociodemographic and clinical variables were recorded. Pearson correlation, independent t-test, and multivariable linear regression were applied; results are presented as β coefficients with 95% confidence intervals (CI). Results: Mean age was 21.26±4.58 years and BMI 23.56±5.72 kg/m². Mood had the lowest QoL score (5.01±1.82). BMI negatively correlated with all domains (r=-0.27 to -0.32; p≤0.002). In adjusted models, BMI independently predicted poorer Impact (β=-0.10; 95%CI -0.15, -0.05; p<0.001), Infertility (β=-0.08; 95%CI -0.13, -0.04; p=0.001), Hirsutism (β=-0.11; 95%CI -0.17, -0.06; p<0.001), and Mood (β=-0.12; 95%CI -0.18, -0.06; p<0.001). Urban residence predicted poorer Mood (β=-1.23; 95%CI -1.90, -0.57; p<0.001). Conclusion: PCOS significantly impairs QoL, particularly psychological well-being. Higher BMI and urban residence are key determinants, underscoring the need for integrated lifestyle and psychological care.

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