Herein, we report a divergent radical cascade reaction of alkyne-tethered ketoximes with a cyanobenziodoxolone (CBX) reagent. Simply by modulating the reaction temperature, this process enables switchable and efficient access to a series of structurally valuable cyano-substituted isoxazolines and 3H-pyrrol-3-ones. Notably, this protocol is characterized by low catalyst loading, broad substrate scope, and operational simplicity. Furthermore, the cyano-containing isoxazolines were obtained with excellent Z-selectivity.
Han et al. (Mon,) studied this question.