Early cardiac sympathetic denervation in hereditary transthyretin amyloidosis: 123I-metaiodobenzylguanidine findings and correlation with skin biopsy.

Resultado clave

Reduced l-H/M on 123I-mIBG indicates early cardiac sympathetic denervation before symptoms in hereditary ATTR amyloidosis; combining with skin biopsy improves early detection.

Puntos clave

• To investigate early cardiac sympathetic denervation in hereditary transthyretin amyloidosis using advanced imaging and biopsy techniques.
• Analyzing l-H/M ratio from ¹²³I-mIBG imaging
• Performing skin biopsies for corroborative assessment
• Correlating imaging findings with clinical symptoms
• Reduced l-H/M ratio indicates early cardiac sympathetic denervation
• Skin biopsy findings support enhanced detection of cardiac issues
• Combined ¹²³I-mIBG and skin biopsy methods improve risk stratification