Chondroitinase Versus Papain Digestion Leads to Different Outcome for In Vitro Simulation of Degenerated Discs.

Puntos clave

• This research aims to compare the effects of chondroitinase and papain on simulating disc degeneration.
• Used in vitro models to test effects of chondroitinase and papain on disc structures.
• Assessed preservation of annulus integrity after enzyme treatment.
• Compared degeneration simulation outcomes between the two enzymes.
• Chondroitinase more effectively simulates disc degeneration than papain.
• Papain provides a better model for nucleotomies.
• Both enzymes maintain annulus integrity during testing.