Plasma and urine biomarker algorithm versus systematic biopsy for prostate cancer detection in elderly men: a randomised trial with early termination for futility | Synapse
March 7, 2026Open Access
Plasma and urine biomarker algorithm versus systematic biopsy for prostate cancer detection in elderly men: a randomised trial with early termination for futility
Puntos clave
To compare the effectiveness of a biomarker algorithm against systematic biopsy for detecting prostate cancer in elderly men.
Conducted a randomised trial with participants assigned to biomarker algorithm or systematic biopsy.
Measured the number of biopsies performed and the detection rates of clinically significant prostate cancers.
Assessed quality of life for both approaches.
The biomarker algorithm reduced the number of biopsies required.
Fewer clinically significant prostate cancers were detected by the biomarker strategy.
Quality of life remained similar between the two methods.
Resumen
The biomarker-based algorithm-triage reduced biopsy numbers but also detected fewer -clinically significant prostate cancers. Quality of life was comparable between approaches.