What question did this study set out to answer?

To highlight the occurrence of steroid-dependent encephalopathy in patients with paraneoplastic neurological syndrome despite negative onconeural antibodies.

March 7, 2026Open Access

Improvement of Steroid-Dependent Encephalopathy Clinically Diagnosed as Paraneoplastic Neurological Syndrome in Onconeural Antibody-Negative Sigmoid Colon Cancer after Laparoscopic Tumor Resection

Puntos clave

To highlight the occurrence of steroid-dependent encephalopathy in patients with paraneoplastic neurological syndrome despite negative onconeural antibodies.
Detailed examination of a case with sigmoid colon cancer and onconeural antibody-negative PNS
Monitoring of patient symptoms during steroid tapering
Assessment of symptom improvement post-laparoscopic tumor resection and radiofrequency ablation
The patient experienced impaired consciousness linked to PNS
Symptoms recurred with steroid tapering
Significant symptom improvement was observed after primary tumor resection and metastasis ablation

Resumen

INTRODUCTION: Paraneoplastic neurological syndrome (PNS) is a rare complication of malignancy caused by immune-mediated mechanisms. Although characteristic onconeural antibodies are useful for the diagnosis of PNS, 30%–40% of cases are seronegative, which makes recognition difficult. We present a case of sigmoid colon cancer complicated by onconeural autoantibody-negative PNS which caused impaired consciousness. The patient’s symptoms recurred with steroid tapering but improved after resection of the primary tumor and radiofrequency ablation (RFA) of the metastasis. This case highlights the importance of considering PNS, even when onconeural antibodies are negative.

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