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March 7, 2026

Coexistence of hepatopulmonary syndrome and portopulmonary hypertension before a liver transplantation: a case report and review of the literature

Puntos clave

To explore the coexistence of hepatopulmonary syndrome and portopulmonary hypertension in liver transplant candidates.
Case report detailing a cirrhotic patient's condition before liver transplantation.
Literature review on the prevalence and management of both pulmonary disorders.
Assessment of treatment strategies for pulmonary hypertension pre-transplant.
Successful management of portopulmonary hypertension enabled liver transplantation.
Favorable outcomes observed three years post-transplant.
Findings suggest that the combination of HPS and PoPH may be more common than previously thought.

Resumen

Liver transplantation remains the treatment of choice for hepatopulmonary syndrome (HPS) with severe hypoxemia, but portopulmonary hypertension (PoPH) has traditionally been viewed as a contraindication to liver transplantation owing to its frequent posttransplant deterioration. We describe here the sequential presence of both pulmonary vascular disorders in a cirrhotic patient in the pretransplant period. Liver transplantation was made possible following effective management of pulmonary hypertension, with favorable outcome 3 years post-liver transplantation. Finally, our case report and literature review suggest that the coexistence of HPS and PoPH in patients with advanced liver disease could be more common than previously recognized.

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