Association of Glucagon-Like Peptide-1 Receptor Agonists and Suicidality: A Systematic Review. | Synapse
March 8, 2026
Association of Glucagon-Like Peptide-1 Receptor Agonists and Suicidality: A Systematic Review.
Puntos clave
To investigate the potential association between glucagon-like peptide-1 receptor agonist exposure and suicidality.
Conducted a systematic review of existing reports
Analyzed data regarding GLP-1 receptor agonists
Evaluated reported incidences of suicidality
No clear causality between GLP-1 receptor agonists and suicidality was established
Reports on suicidality in relation to GLP-1 receptor agonists exist but lack definitive conclusions
Resumen
Reports of aspects of suicidality and exposure to select GLP-1 RAs exist; notwithstanding, no causality between GLP-1 RA exposure and suicidality is apparent.