Elevated circulating ADGV was associated with a 1.52 to 1.79-fold increased odds of prevalent hypertriglyceridemia in adults aged 30-65 in Southern China after multivariable adjustment.
Observational (n=588)
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Is elevated circulating ADGV associated with an increased risk of prevalent and incident hypertriglyceridemia?
Higher circulating ADGV is independently associated with prevalent and incident hypertriglyceridemia, suggesting it may serve as a biomarker and contributory factor in early dyslipidemia and hepatic lipogenesis.
Estimación del efecto: OR 1.52-1.79 across adjusted models
Tasa de eventos absoluta: 51.02% vs 36.73%
valor p: p=<0.05
Higher circulating ADGV was independently associated with prevalent and incident hypertriglyceridemia across a cross-sectional cohort and an independent prospective cohort, and hepatocyte experiments support a contributory role of ADGV in hepatic lipogenesis.
Han et al. (Sat,) conducted a observational in Adults aged 30-65 years residing in Southern China with or without hypertriglyceridemia and metabolic abnormalities (n=588). Elevated circulating asymmetric dimethylguanidino valeric acid (ADGV) vs. Lower ADGV levels (below median) was evaluated on Prevalent hypertriglyceridemia (fasting triglyceride concentration ≥ 1.7 mmol/L) (OR 1.52-1.79 across adjusted models, p=<0.05). Elevated circulating ADGV was associated with a 1.52 to 1.79-fold increased odds of prevalent hypertriglyceridemia in adults aged 30-65 in Southern China after multivariable adjustment.