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Olpasiran therapy significantly reduced lipoprotein(a) concentrations in patients with established atherosclerotic cardiovascular disease. Longer and larger trials will be necessary to determine the effect of olpasiran therapy on cardiovascular disease. (Funded by Amgen; OCEANa-DOSE ClinicalTrials.gov number, NCT04270760.).
O’Donoghue et al. (Sun,) studied this question.