The parotid salivary gland is a critical structure in the maxillofacial region that exhibits intricate anatomical relationships with neurovascular elements.These relationships are significantly shaped by embryonic development.This article summarizes current knowledge on the embryogenesis, anatomical organization, and clinical relevance of the parotid gland, emphasizing how developmental processes dictate its adult morphology.The parotid gland embryologically originates from the ectodermal oral epithelium at 8-9 weeks of gestation and undergoes branching morphogenesis, which is regulated by growth factors (FGF, TGF, and EGF), extracellular matrix components (collagen III/IV and fibronectin), and genetic mechanisms (e.g., microRNA-21).Apoptosis-driven lumen formation and myoepithelial cell differentiation refine ductal architecture further by mid-gestation.Postnatally, hypoxia and signaling pathways continue to influence maturation.Anatomically, the gland's lobular structure is divided into superficial and deep lobes by the facial nerve and exhibits variability in processes (e.g., temporal and facial) and ductal anatomy.The gland's close association with the facial nerve, external carotid artery, and parotid fascia highlights the complexity of surgery.Topographic variability, such as the presence of accessory glandular tissue (prevalent in 32-36 % of cases) and ductal branching patterns, impacts diagnostic and therapeutic precision.Clinical correlations underscore the importance of embryological knowledge in managing neoplasms, trauma, and iatrogenic nerve injuries.Understanding the developmental determinants of glandular architecture and neurovascular relationships improves procedural accuracy in maxillofacial surgery and reduces morbidity.This review emphasizes the interdependence of embryology, anatomy, and clinical practice, advocating for an integrated approach to managing parotid pathology.
Zharikov et al. (Mon,) studied this question.