What is the clinical evidence from this study?

Study design: Cohort. Population: Obesity (n=93). Intervention: Sleeve Gastrectomy. Primary outcome: Carotid Intima-Media Thickness (CIMT) (p=<0.001).

What question did this study set out to answer?

This research aims to investigate the effects of sleeve gastrectomy on carotid intima-media thickness and associated biomarkers.

March 13, 2026Open Access

Carotid Intima–media Thickness is Lower after Sleeve Gastrectomy, with Concurrent Changes in Oxidized LDL and PAI-1

Q: What are the key findings of this study?

Sleeve gastrectomy reduced carotid intima-media thickness from 1.0 mm to 0.6 mm after one year, indicating significant improvement in vascular health.

Q: What question did this study set out to answer?

This research aims to investigate the effects of sleeve gastrectomy on carotid intima-media thickness and associated biomarkers.

Resultado clave

Sleeve gastrectomy reduced carotid intima-media thickness from 1.0 mm to 0.6 mm after one year, indicating significant improvement in vascular health.

Puntos clave

This research aims to investigate the effects of sleeve gastrectomy on carotid intima-media thickness and associated biomarkers.
Employed assessments of carotid intima-media thickness (CIMT) before and after sleeve gastrectomy (SG)
Measured levels of oxidative and inflammatory biomarkers, including oxidized LDL (Ox-LDL) and PAI-1
Evaluated the relationship between CIMT and various fibrinolysis biomarkers post-SG
CIMT decreased significantly after sleeve gastrectomy
Oxidized LDL showed a stronger correlation with CIMT compared to PAI-1
Improvements were observed in inflammatory and oxidative biomarkers post-weight loss

Diseño del estudio

Tipo

Cohort (n=93)

Multicéntrico

PICO estructurado

Does sleeve gastrectomy improve carotid intima-media thickness and oxidative/fibrinolytic biomarkers in adults with obesity?

Población

93 adults with obesity (BMI > 35 kg/m² or BMI > 30 kg/m² with at least one obesity-associated disease), mean age 39.6, 82.8% female. Excluded: history of clinically manifest atherosclerotic cardiovascular disease, known coagulopathies, or current malignancy.

Intervención

Laparoscopic sleeve gastrectomy (SG)

Resultado

Changes in carotid intima-media thickness (CIMT), oxidized LDL (ox-LDL), and PAI-1 at 12 months postoperativelysurrogate

Sleeve gastrectomy significantly reduces subclinical atherosclerosis (CIMT) and improves cardiometabolic biomarkers, with ox-LDL serving as a better predictor of vascular risk than PAI-1.

Resultado numérico

Tasa de eventos absoluta: 0.6% vs 1%

valor p: p=<0.001

Limitaciones

Single-center study
Modest sample size limits generalizability
No control group without obesity
Medications during follow-up not systematically recorded

Resumen

Weight loss following SG was associated with improvement in inflammatory, oxidative, and fibrinolytic biomarkers. Ox-LDL was more strongly linked to CIMT than PAI-1, which showed limited predictive value. Further studies are needed to evaluate the relationship between CIMT and other fibrinolysis biomarkers such as thrombin-activatable fibrinolysis inhibitor (TAFI) and D-dimer in the context of MBS.

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Cite This Study

Hany et al. (Wed,) conducted a cohort in Obesity (n=93). Sleeve Gastrectomy was evaluated on Carotid Intima-Media Thickness (CIMT) (p=<0.001). Sleeve gastrectomy reduced carotid intima-media thickness from 1.0 mm to 0.6 mm after one year, indicating significant improvement in vascular health.

synapsesocial.com/papers/69b3ac6002a1e69014cce01b https://doi.org/https://doi.org/10.1007/s11695-026-08538-z

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