Carriers of genetic variants related to familial hypercholesterolemia had significantly higher counts of PS+-EVs, CardioEVs, EEVs, and TFEVs compared to non-carrier family members.
Observational (n=32)
Sí
Does the presence of familial hypercholesterolemia-related genetic variants increase circulating extracellular vesicle counts compared to non-carrier family members?
Familial hypercholesterolemia is associated with increased circulating extracellular vesicles derived from cardiomyocytes and endothelial cells, suggesting their potential role as early markers of cardiovascular injury.
Estimación del efecto: p = 0.040 (PS+-EVs), p = 0.010 (CardioEVs), p = 0.010 (EEVs), p = 0.010 (TFEVs)
valor p: p=<0.001 (LDL-c levels)
The data suggest that EVs are related to FH and that their cellular origins could be related to cardiovascular complications commonly observed in this disease.
Silvino et al. (Wed,) conducted a observational in Familial hypercholesterolemia (n=32). Carriers of genetic variants related to familial hypercholesterolemia had significantly higher counts of PS+-EVs, CardioEVs, EEVs, and TFEVs compared to non-carrier family members.