What question did this study set out to answer?

This research examines the prognostic value of the CRP-Albumin-Lymphocyte Index in triple-negative breast cancer patients.

March 15, 2026Open Access

Prognostic Significance of the CRP-Albumin-Lymphocyte Index (CALLY) in Triple Negative Breast Cancer Patients: A Real-World Retrospective Study

Puntos clave

This research examines the prognostic value of the CRP-Albumin-Lymphocyte Index in triple-negative breast cancer patients.
Retrospective analysis of 172 TNBC patients treated surgically from January 2011 to December 2020.
Utilized Kaplan-Meier method for estimating survival curves for DFS and OS.
Constructed univariate and multivariate Cox proportional hazards regression models.
Developed nomograms based on multivariate results, validated using C-index and decision curve analyses.
Patients with high CALLY exhibited significantly prolonged DFS (32.54 vs. 28.97 months; P=0.0002) and OS (59.87 vs. 45.20 months; P<0.0001).
CALLY was identified as an independent predictor of DFS (HR: 0.275; P<0.001) and OS (HR: 0.372; P=0.007).
Nomograms integrating CALLY demonstrated good predictive accuracy for DFS (C-index: 0.717) and OS (C-index: 0.725).

Resumen

Objective: This study aims to explore the prognostic utility of the CRP-Albumin- Lymphocyte Index (CALLY) in triple-negative breast cancer (TNBC) patients undergoing curative resection. Methods: A retrospective analysis of 172 TNBC patients treated surgically between January 2011 and December 2020 was conducted. Preoperative CALLY was calculated as (albumin × lymphocyte) / CRP Survival curves for disease free survival (DFS) and overall survival (OS) were estimated using Kaplan-Meier method, and differences between groups were statistically evaluated by Log rank test. Univariate and multivariate Cox proportional hazards regression model were constructed incorporating variables identified as potential independent variables. Nomograms were established according to the multivariate analysis results, and with internal validation performed using the consistency index (C-index), calibration curve, and decision curve analyses (DCA). Results: Patients were stratified into low CALLY group (< 0.44, n=83) and high CALLY group (≥ 0.44, n=89) based on the optimal cutoff value of CALLY determined by receiver operating characteristic curve (ROC) analysis. High CALLY correlated with significantly prolonged DFS (32.54 vs. 28.97 months; χ 2 =14.070, P=0.0002) and OS (59.87 vs. 45.20 months; χ 2 =17.800, P< 0.0001). Multivariate regression analysis revealed that CALLY as an independent predictor of DFS (hazard ratio HR: 0.275, 95% confidence interval CI: 0.140– 0.539, P< 0.001) and OS (HR: 0.372, 95% CI: 0.182– 0.764, P = 0.007). Nomograms integrating CALLY, TOP2A, and postoperative chemotherapy demonstrated robust predictive accuracy for DFS (C-index: 0.717, 95% CI 0.595– 0.814) and OS (C-index: 0.725, 95% CI 0.605– 0.819). Conclusion: CALLY reflects systemic inflammation, nutrition, and immune status, and represents a novel prognostic index for TNBC. Its integration into nomograms enhances personalized risk stratification and treatment decision-making. Keywords: triple negative breast cancer, CRP-Albumin-Lymphocyte Index, TOP2A, chemotherapy, survival

Leer artículo completoexternamente

Me gusta

Guardar

Ver artículo completo