What question did this study set out to answer?

To identify shared molecular features between diabetic and chemotherapy-induced peripheral neuropathy.

March 15, 2026Open Access

EXPRESS: Consensus co-expression analysis identifies a common set of co-expressed genes associated with diabetic peripheral neuropathy and chemotherapy-induced peripheral neuropathy

Puntos clave

To identify shared molecular features between diabetic and chemotherapy-induced peripheral neuropathy.
Conducted consensus co-expression analysis of gene expression data.
Focused on co-expressed genes associated with neuropathic conditions.
Analyzed metabolic reprogramming and stress responses.
Revealed a common set of co-expressed genes in both conditions.
Highlighted pathways related to metabolic reprogramming and programmed cell death.
Provided insights for developing targeted therapies addressing shared mechanisms.

Resumen

Our analysis reveals a convergent molecular signature underlying both DPN and CIPN, centered on metabolic reprogramming, transcriptional stress, and programmed cell death. These findings provide a systems-level framework for developing therapies targeting shared pathological mechanisms.

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